HOW SHOULD THIS MEDICINE BE USED?
Lotensin HCT® (benazepril hydrochloride and hydrochlorothiazide) Tablets come in tablet form, which can be taken by mouth. The specific dosage of Lotensin HCT that your doctor prescribes for you will depend on your medical condition and your response to treatment.
Lotensin HCT may be taken with or without food. Use this medicine as your doctor prescribed. Take Lotensin HCT at the same time each day in order to get the most benefit from it. Do not take this medicine in larger or smaller amounts or for longer than your doctor recommends. Do not suddenly stop taking this medicine without consulting your doctor because your condition may worsen if you stop taking Lotensin HCT.
The conditions that may cause low blood pressure include vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low salt diet or taking diuretics (water pills). Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting.
Your blood pressure will need to be checked often. Your kidney function may also need to be checked. Your blood and urine may also be tested if you have been vomiting or are dehydrated. Always tell your doctor if you have any abnormal symptoms.
Because of the potential for serious side effects to an unborn child, DO NOT USE THIS MEDICINE IF YOU ARE PREGNANT. TELL YOUR DOCTOR RIGHT AWAY IF YOU BECOME PREGNANT SO HE OR SHE CAN SLOWLY TAKE YOU OFF THIS MEDICINE.
WHO SHOULD NOT TAKE LOTENSIN HCT® (benazepril hydrochloride and hydrochlorothiazide) Tablets?
DO NOT USE THIS MEDICINE IF YOU ARE PREGNANT. TELL YOUR DOCTOR RIGHT AWAY IF YOU BECOME PREGNANT.
If you have diabetes, do not use Lotensin HCT with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo, Valturna).
You should not use this medication if you are allergic to hydrochlorothiazide (HCTZ, HydroDiuril, Hyzaar, Vaseretic, Zestoretic), benazepril (Lotensin) or any ACE inhibitor (captopril, enalapril, lisinopril, ramipril, and others) or if you have ever have angioedema (hives or severe swelling of deep skin tissues sometimes caused by allergic reaction).
Do not take Lotensin HCT after the expiry date printed on the bottle label or if the packaging is torn or shows signs of tampering.
Before you start to take Lotensin HCT:
Tell your doctor if you have any of the following health problems/medical conditions:
- You are pregnant, planning to become pregnant, or are breast-feeding
- You are able to become pregnant
- You are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- You are a diabetic
- You have allergies to medicines, foods, or other substances
- You have a history of heart problems (e.g., heart failure, aortic stenosis), blood vessel problems, blood flow problems, bone marrow problems, kidney problems (e.g., renal artery stenosis), liver problems, high cholesterol or lipid levels, diabetes, or gout
- You have a history of a stroke, a recent heart attack, a kidney transplant, allergies, or asthma
- You have an autoimmune disease (e.g., rheumatoid arthritis, lupus, scleroderma)
- You are dehydrated, have low blood volume, or low blood pressure
- You have high blood potassium levels, low blood sodium levels, or are on a low-salt (sodium) diet
- You are receiving treatments to reduce sensitivity to bee or wasp stings
- You are having dialysis or apheresis or are scheduled to have surgery, or receive anesthesia
- You have recently had a certain type of nerve surgery (sympathectomy)
- You have never taken another medicine for high blood pressure
TAKING OTHER MEDICINES:
Some MEDICINES MAY INTERACT with benazepril or hydrochlorothiazide. Tell your doctor if you are taking any other medicines, especially any of the following:
- Digoxin, dofetilide, or ketanserin because the risk of irregular heartbeat may be increased
- Everolimus or sirolimus because the risk of angioedema may be increased
- Adrenocorticotropic hormone (ACTH), corticosteroids (e.g., prednisone), dextran sulfate, diazoxide, diuretics (e.g., furosemide), or other medicines for high blood pressure because an increased risk of low blood pressure may occur
- Aliskiren or angiotensin receptor blockers (ARBs) (e.g., losartan) because the risk of certain side effects (e.g., serious kidney problems, high blood potassium levels, low blood pressure) may be increased
- Eplerenone, potassium-sparing diuretics (e.g., spironolactone, triamterene), potassium supplements, salt substitutes containing potassium, or trimethoprim because the risk of high blood potassium levels may be increased
- Certain gold-containing medicines (e.g., sodium aurothiomalate) because flushing, nausea, vomiting, and low blood pressure may occur
- Nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g., celecoxib, ibuprofen, indomethacin) because the risk of serious damage to the kidneys (e.g., decrease in amount of urine, weight gain) may be increased or they may decrease benazepril or hydrochlorothiazide’s effectiveness
- Lithium or thiopurines (e.g., azathioprine) because the risk of their side effects may be increased by benazepril or hydrochlorothiazide
- Insulin or other diabetes medicines (e.g., glyburide ) because their effectiveness may be decreased by benazepril or hydrochlorothiazide
This may not be a complete list of all interactions that may occur. Ask your doctor if benazepril or hydrochlorothiazide may interact with any other medicines that you are taking. Check with your doctor before you start, stop, or change the dose of any medicine.
Be sure to tell your doctor about any conditions you have before you start taking Lotensin HCT.
Do NOT use Lotensin HCT if:
- You are allergic to any ingredient in benazepril or hydrochlorothiazide, any other sulfonamide medicine (e.g., sulfamethoxazole, glyburide, probenecid), or other ACE inhibitors (e.g., lisinopril)
- You have a history of angioedema (swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or unusual hoarseness)
- You are unable to urinate
- You are pregnant
- You are also taking aliskiren and you have either diabetes or kidney problems
- You are also taking dofetilide or ketanserin
Contact your doctor or health care provider right away if any of these apply to you.